{"id":18,"date":"2026-02-15T16:45:37","date_gmt":"2026-02-15T16:45:37","guid":{"rendered":"http:\/\/behavior-tools.com\/?page_id=18"},"modified":"2026-02-15T16:53:41","modified_gmt":"2026-02-15T16:53:41","slug":"social-preference-test","status":"publish","type":"page","link":"https:\/\/behavior-tools.com\/index.php\/social-preference-test\/","title":{"rendered":"SOCIAL PREFERENCE TEST (FR)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">R\u00e9sum\u00e9 scientifique<\/h2>\n\n\n\n<p>Le Social Preference Test (SPT) \u00e9value la motivation sociale et la reconnaissance cong\u00e9n\u00e9rique chez le zebrafish adulte. Il constitue un outil central pour l\u2019\u00e9tude des troubles neurod\u00e9veloppementaux (mod\u00e8les ASD), des psychostimulants et des perturbateurs endocriniens.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">1. Contexte historique<\/h2>\n\n\n\n<p>Les premi\u00e8res observations quantitatives du comportement social chez le zebrafish remontent \u00e0 :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Robert Gerlai (2000\u20132008)<\/li>\n<\/ul>\n\n\n\n<p>\u00c9tudes fondatrices :<\/p>\n\n\n\n<p>Gerlai et al., 2000. <em>Behavioral Brain Research<\/em><br>DOI: 10.1016\/S0166-4328(99)00167-5<\/p>\n\n\n\n<p>Saverino &amp; Gerlai, 2008. <em>Behavioural Brain Research<\/em><br>DOI: 10.1016\/j.bbr.2007.10.024<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">2. Fondements neurobiologiques<\/h2>\n\n\n\n<p>Impliqu\u00e9s :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Syst\u00e8me dopaminergique (motivation sociale)<\/li>\n\n\n\n<li>Ocytocine\/vasotocine<\/li>\n\n\n\n<li>S\u00e9rotonine<\/li>\n\n\n\n<li>R\u00e9seau pallial t\u00e9l\u00e9ost\u00e9en (homologue cortex limbique)<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">3. Objectif scientifique<\/h2>\n\n\n\n<p>Mesurer :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Attraction sociale<\/li>\n\n\n\n<li>Reconnaissance cong\u00e9n\u00e9rique<\/li>\n\n\n\n<li>Effets des mutations g\u00e9n\u00e9tiques<\/li>\n\n\n\n<li>Alt\u00e9rations neurod\u00e9veloppementales<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">4. M\u00e9thodologie exp\u00e9rimentale standardis\u00e9e<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Dispositif<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cuve 3 compartiments (60 \u00d7 15 \u00d7 20 cm)<\/li>\n\n\n\n<li>Compartiment central : poisson test<\/li>\n\n\n\n<li>Compartiment lat\u00e9ral : groupe stimulus (3\u20135 poissons)<\/li>\n\n\n\n<li>Zone vide contr\u00f4le oppos\u00e9e<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Conditions<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Eau 28 \u00b0C<\/li>\n\n\n\n<li>Lumi\u00e8re diffuse 80\u2013120 lux<\/li>\n\n\n\n<li>Dur\u00e9e : 10 minutes<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Param\u00e8tres mesur\u00e9s<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Temps pass\u00e9 zone sociale (%)<\/li>\n\n\n\n<li>Distance moyenne au stimulus<\/li>\n\n\n\n<li>Nombre d\u2019approches<\/li>\n\n\n\n<li>Vitesse moyenne<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Contr\u00f4les positifs<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fluox\u00e9tine (augmentation sociabilit\u00e9)<\/li>\n\n\n\n<li>MK-801 (diminution sociabilit\u00e9)<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">5. Analyse statistique<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ratio pr\u00e9f\u00e9rence sociale<\/li>\n\n\n\n<li>ANOVA factorielle<\/li>\n\n\n\n<li>Mod\u00e8les lin\u00e9aires mixtes<\/li>\n\n\n\n<li>Correction de Bonferroni<\/li>\n\n\n\n<li>Analyse multivari\u00e9e si plusieurs endpoints<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">6. Applications<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mod\u00e8les ASD (shank3, cntnap2)<\/li>\n\n\n\n<li>Perturbateurs endocriniens<\/li>\n\n\n\n<li>\u00c9tudes dopaminergiques<\/li>\n\n\n\n<li>Neurotoxicit\u00e9 d\u00e9veloppementale<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">7. Limites<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Influence locomotion<\/li>\n\n\n\n<li>Stress d\u2019isolement<\/li>\n\n\n\n<li>Effets dominance<\/li>\n\n\n\n<li>Habituation rapide<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">8. Section OCDE<\/h2>\n\n\n\n<p>Pas encore valid\u00e9 comme endpoint primaire OCDE.<\/p>\n\n\n\n<p>Applicable en compl\u00e9ment de :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>OECD TG 236 (FET)<\/li>\n\n\n\n<li>OECD TG 210 (Early-Life Stage)<\/li>\n<\/ul>\n\n\n\n<p>Int\u00e9r\u00eat croissant pour int\u00e9gration dans tests de neurotoxicit\u00e9 d\u00e9veloppementale (DNT battery).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">9. R\u00e9f\u00e9rences (r\u00e9centes \u2192 anciennes)<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Tang et al., 2020. Social behavior deficits in zebrafish ASD models. <em>Translational Psychiatry<\/em>. DOI: 10.1038\/s41398-020-0783-7<\/li>\n\n\n\n<li>Buske &amp; Gerlai, 2011. Shoaling development. <em>Developmental Psychobiology<\/em>. DOI: 10.1002\/dev.20581<\/li>\n\n\n\n<li>Saverino &amp; Gerlai, 2008. The social zebrafish. <em>Behavioural Brain Research<\/em>. DOI: 10.1016\/j.bbr.2007.10.024<\/li>\n\n\n\n<li>Gerlai et al., 2000. Social behavior in zebrafish. <em>Behavioral Brain Research<\/em>. DOI: 10.1016\/S0166-4328(99)00167-5<br>5\u201310. [\u00c9tudes compl\u00e9mentaires dopaminergiques, ASD, neurotoxiques]<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>R\u00e9sum\u00e9 scientifique Le Social Preference Test (SPT) \u00e9value la motivation sociale et la reconnaissance cong\u00e9n\u00e9rique chez le zebrafish adulte. Il constitue un outil central pour l\u2019\u00e9tude des troubles neurod\u00e9veloppementaux (mod\u00e8les ASD), des psychostimulants et des perturbateurs endocriniens. 1. Contexte historique Les premi\u00e8res observations quantitatives du comportement social chez le zebrafish remontent \u00e0 : \u00c9tudes fondatrices [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":2,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":21,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/18\/revisions\/21"}],"wp:attachment":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}