{"id":2,"date":"2026-02-14T19:27:25","date_gmt":"2026-02-14T19:27:25","guid":{"rendered":"http:\/\/behavior-tools.com\/?page_id=2"},"modified":"2026-02-15T16:53:55","modified_gmt":"2026-02-15T16:53:55","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/behavior-tools.com\/index.php\/sample-page\/","title":{"rendered":"OPEN FIELD TEST (FR)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">R\u00e9sum\u00e9 scientifique<\/h2>\n\n\n\n<p>L\u2019Open Field Test (OFT) chez le zebrafish adulte est un paradigme d\u2019exploration locomotrice et d\u2019\u00e9valuation de l\u2019anxi\u00e9t\u00e9 d\u00e9riv\u00e9 des mod\u00e8les murins d\u00e9velopp\u00e9s par Hall en 1934. Adapt\u00e9 aux poissons t\u00e9l\u00e9ost\u00e9ens dans les ann\u00e9es 2000, il est aujourd\u2019hui un test central en neuropharmacologie et toxicologie comportementale.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">1. Contexte historique<\/h2>\n\n\n\n<p>Le concept original d\u2019open field a \u00e9t\u00e9 introduit par :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Calvin S. Hall (1934)<\/li>\n<\/ul>\n\n\n\n<p>Adaptation au zebrafish :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>2006\u20132010 : standardisation comportementale<\/li>\n\n\n\n<li>R\u00e9f\u00e9rence fondatrice :<br>Maximino et al., 2010<br>DOI: 10.1016\/j.bbr.2009.12.031<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">2. Fondements neurobiologiques<\/h2>\n\n\n\n<p>Impliqu\u00e9s :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Syst\u00e8me s\u00e9rotoninergique<\/li>\n\n\n\n<li>Dopaminergique<\/li>\n\n\n\n<li>Axe HPI (Hypothalamic\u2013Pituitary\u2013Interrenal)<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">3. Objectif scientifique<\/h2>\n\n\n\n<p>\u00c9valuer :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Thigmotaxie<\/li>\n\n\n\n<li>Activit\u00e9 locomotrice<\/li>\n\n\n\n<li>Anxi\u00e9t\u00e9<\/li>\n\n\n\n<li>Exploration<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">4. M\u00e9thodologie exp\u00e9rimentale standardis\u00e9e<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Installation<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cuve carr\u00e9e : 20 \u00d7 20 \u00d7 15 cm<\/li>\n\n\n\n<li>Eau : 28 \u00b1 0.5 \u00b0C<\/li>\n\n\n\n<li>\u00c9clairage : 100 lux<\/li>\n\n\n\n<li>Dur\u00e9e : 6 minutes<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Proc\u00e9dure<\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Acclimatation 30 min en salle exp\u00e9rimentale<\/li>\n\n\n\n<li>Transfert individuel<\/li>\n\n\n\n<li>Enregistrement vid\u00e9o 30 fps<\/li>\n\n\n\n<li>Analyse automatis\u00e9e recommand\u00e9e<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\">Param\u00e8tres primaires<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Distance totale (cm)<\/li>\n\n\n\n<li>Temps centre vs p\u00e9riph\u00e9rie<\/li>\n\n\n\n<li>Nombre d\u2019entr\u00e9es centre<\/li>\n\n\n\n<li>Vitesse moyenne<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Contr\u00f4les<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Diaz\u00e9pam 1 mg\/L (contr\u00f4le anxiolytique)<\/li>\n\n\n\n<li>Caf\u00e9ine 100 mg\/L (contr\u00f4le anxiog\u00e8ne)<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">5. Analyse statistique<\/h2>\n\n\n\n<p>Power \u2265 0.8<\/p>\n\n\n\n<p>Test Shapiro-Wilk<\/p>\n\n\n\n<p>ANOVA \u00e0 un facteur<\/p>\n\n\n\n<p>Post hoc Tukey<\/p>\n\n\n\n<p>Taille d\u2019effet \u03b7\u00b2<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">6. Applications<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Screening anxiolytique<\/li>\n\n\n\n<li>Neurotoxicit\u00e9 subl\u00e9tale<\/li>\n\n\n\n<li>Effets des m\u00e9taux lourds<\/li>\n\n\n\n<li>\u00c9tudes CRISPR knock-out<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">7. Limites<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Confusion anxi\u00e9t\u00e9 vs hypoactivit\u00e9<\/li>\n\n\n\n<li>Sensibilit\u00e9 au stress de manipulation<\/li>\n\n\n\n<li>Variabilit\u00e9 inter-laboratoire<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">8. Section OCDE<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Lignes directrices pertinentes<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>OECD TG 236 \u2014 Fish Embryo Acute Toxicity (FET)<\/li>\n\n\n\n<li>OECD TG 203 \u2014 Fish Acute Toxicity Test<\/li>\n\n\n\n<li>OECD TG 210 \u2014 Fish Early-Life Stage Toxicity Test<\/li>\n<\/ul>\n\n\n\n<p>L\u2019OFT peut servir comme :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Endpoint comportemental compl\u00e9mentaire<\/li>\n\n\n\n<li>Biomarker subl\u00e9tal non l\u00e9tal<\/li>\n\n\n\n<li>Outil pr\u00e9dictif de neurotoxicit\u00e9 pr\u00e9coce<\/li>\n<\/ul>\n\n\n\n<p>Statut r\u00e9glementaire :<br>Non encore valid\u00e9 comme endpoint primaire OCDE, mais de plus en plus int\u00e9gr\u00e9 dans les batteries de toxicit\u00e9 m\u00e9canistique.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">9. R\u00e9f\u00e9rences scientifiques (r\u00e9centes \u2192 anciennes)<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Stewart et al., 2014. Zebrafish models for translational neuroscience. <em>Progress in Neuro-Psychopharmacology &amp; Biological Psychiatry<\/em>. DOI: 10.1016\/j.pnpbp.2013.10.014<\/li>\n\n\n\n<li>Kalueff et al., 2013. Zebrafish neurobehavioral phenomics. <em>Trends in Pharmacological Sciences<\/em>. DOI: 10.1016\/j.tips.2013.07.008<\/li>\n\n\n\n<li>Maximino et al., 2010. Measuring anxiety in zebrafish. <em>Behavioural Brain Research<\/em>. DOI: 10.1016\/j.bbr.2009.12.031<\/li>\n\n\n\n<li>Wong et al., 2010. Behavioral analysis of zebrafish. <em>Nature Protocols<\/em>. DOI: 10.1038\/nprot.2010.119<\/li>\n\n\n\n<li>Blaser &amp; Gerlai, 2006. Behavioral phenotyping in zebrafish. <em>Behavioural Brain Research<\/em>. DOI: 10.1016\/j.bbr.2006.02.005<br>6\u201310.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>R\u00e9sum\u00e9 scientifique L\u2019Open Field Test (OFT) chez le zebrafish adulte est un paradigme d\u2019exploration locomotrice et d\u2019\u00e9valuation de l\u2019anxi\u00e9t\u00e9 d\u00e9riv\u00e9 des mod\u00e8les murins d\u00e9velopp\u00e9s par Hall en 1934. Adapt\u00e9 aux poissons t\u00e9l\u00e9ost\u00e9ens dans les ann\u00e9es 2000, il est aujourd\u2019hui un test central en neuropharmacologie et toxicologie comportementale. 1. Contexte historique Le concept original d\u2019open field [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":6,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":22,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/2\/revisions\/22"}],"wp:attachment":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}