{"id":27,"date":"2026-02-15T17:00:53","date_gmt":"2026-02-15T17:00:53","guid":{"rendered":"http:\/\/behavior-tools.com\/?page_id=27"},"modified":"2026-02-15T17:00:53","modified_gmt":"2026-02-15T17:00:53","slug":"conditioned-place-preference-cpp-fr","status":"publish","type":"page","link":"https:\/\/behavior-tools.com\/index.php\/conditioned-place-preference-cpp-fr\/","title":{"rendered":"CONDITIONED PLACE PREFERENCE (CPP) (FR)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">R\u00e9sum\u00e9 scientifique<\/h2>\n\n\n\n<p>Le Conditioned Place Preference (CPP) est un paradigme pavlovien \u00e9valuant l\u2019association contextuelle entre un environnement distinct et une substance pharmacologiquement active. Chez le zebrafish (Danio rerio), il constitue un mod\u00e8le robuste d\u2019\u00e9tude des m\u00e9canismes de r\u00e9compense, d\u2019addiction et de neuroplasticit\u00e9 dopaminergique.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">1. Contexte historique<\/h2>\n\n\n\n<p>Le CPP a \u00e9t\u00e9 d\u00e9velopp\u00e9 dans les ann\u00e9es 1970 chez le rat pour \u00e9tudier la d\u00e9pendance aux opio\u00efdes.<\/p>\n\n\n\n<p>Adaptation au zebrafish :<\/p>\n\n\n\n<p>Lau et al., 2006. <em>Pharmacology Biochemistry and Behavior<\/em><br>DOI: 10.1016\/j.pbb.2006.06.012<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">2. Fondements neurobiologiques<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Voie m\u00e9solimbique dopaminergique<\/li>\n\n\n\n<li>Aire tegmentale ventrale homologue<\/li>\n\n\n\n<li>Pallium ventral<\/li>\n\n\n\n<li>Plasticit\u00e9 synaptique NMDA-d\u00e9pendante<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">3. Objectif scientifique<\/h2>\n\n\n\n<p>Mesurer :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Propri\u00e9t\u00e9s renfor\u00e7antes<\/li>\n\n\n\n<li>Motivation contextuelle<\/li>\n\n\n\n<li>Sensibilisation comportementale<\/li>\n\n\n\n<li>Effets de sevrage<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">4. M\u00e9thodologie exp\u00e9rimentale standardis\u00e9e<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Dispositif<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cuve \u00e0 deux compartiments distincts (motifs visuels contrast\u00e9s)<\/li>\n\n\n\n<li>Compartiment neutre central (optionnel)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Phase 1 : Pr\u00e9-test (15 min)<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mesure pr\u00e9f\u00e9rence spontan\u00e9e<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Phase 2 : Conditionnement (4\u20138 jours)<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Alternance substance \/ v\u00e9hicule<\/li>\n\n\n\n<li>Dur\u00e9e exposition : 20 min<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Substances de validation<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u00c9thanol (0.5\u20131.5%)<\/li>\n\n\n\n<li>Nicotine (10\u201350 \u00b5g\/L)<\/li>\n\n\n\n<li>Coca\u00efne (5\u201320 mg\/L)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Phase 3 : Test final<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Acc\u00e8s libre 15 min<\/li>\n\n\n\n<li>Mesure temps pass\u00e9 compartiment conditionn\u00e9<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">5. Analyse statistique<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Score CPP = (Post \u2013 Pre)<\/li>\n\n\n\n<li>ANOVA \u00e0 mesures r\u00e9p\u00e9t\u00e9es<\/li>\n\n\n\n<li>Mod\u00e8les mixtes<\/li>\n\n\n\n<li>Cohen\u2019s d<\/li>\n\n\n\n<li>Correction FDR si multi-substances<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">6. Applications<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Addiction alcool<\/li>\n\n\n\n<li>Nicotine<\/li>\n\n\n\n<li>Psychostimulants<\/li>\n\n\n\n<li>Screening antagonistes dopaminergiques<\/li>\n\n\n\n<li>Toxicit\u00e9 d\u00e9veloppementale sur circuits r\u00e9compense<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">7. Limites<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Effets locomoteurs confondants<\/li>\n\n\n\n<li>Pr\u00e9f\u00e9rences inn\u00e9es contextuelles<\/li>\n\n\n\n<li>Variabilit\u00e9 inter-individuelle \u00e9lev\u00e9e<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">8. Section OCDE<\/h2>\n\n\n\n<p>Non inclus dans lignes directrices primaires.<\/p>\n\n\n\n<p>Peut compl\u00e9ter :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>OECD TG 236 (d\u00e9veloppement pr\u00e9coce)<\/li>\n\n\n\n<li>OECD DNT framework (en discussion)<\/li>\n<\/ul>\n\n\n\n<p>Potentiel futur : biomarqueur comportemental de neurotoxicit\u00e9 affectant circuits de r\u00e9compense.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">9. R\u00e9f\u00e9rences (r\u00e9centes \u2192 anciennes)<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Kacprzak et al., 2017. Alcohol CPP in zebrafish. <em>Addiction Biology<\/em>. DOI: 10.1111\/adb.12328<\/li>\n\n\n\n<li>Ninkovic &amp; Bally-Cuif, 2006. Zebrafish addiction model. <em>Developmental Neurobiology<\/em>. DOI: 10.1002\/dneu.20308<\/li>\n\n\n\n<li>Lau et al., 2006. Nicotine CPP in zebrafish. <em>Pharmacology Biochemistry and Behavior<\/em>. DOI: 10.1016\/j.pbb.2006.06.012<br>4\u201310. [Coca\u00efne, NMDA plasticit\u00e9, antagonistes D1\/D2]<\/li>\n<\/ol>\n\n\n\n<ul class=\"wp-block-list\"><\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>R\u00e9sum\u00e9 scientifique Le Conditioned Place Preference (CPP) est un paradigme pavlovien \u00e9valuant l\u2019association contextuelle entre un environnement distinct et une substance pharmacologiquement active. Chez le zebrafish (Danio rerio), il constitue un mod\u00e8le robuste d\u2019\u00e9tude des m\u00e9canismes de r\u00e9compense, d\u2019addiction et de neuroplasticit\u00e9 dopaminergique. 1. Contexte historique Le CPP a \u00e9t\u00e9 d\u00e9velopp\u00e9 dans les ann\u00e9es 1970 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-27","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/27","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/comments?post=27"}],"version-history":[{"count":1,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/27\/revisions"}],"predecessor-version":[{"id":28,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/27\/revisions\/28"}],"wp:attachment":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/media?parent=27"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}