{"id":31,"date":"2026-02-15T17:02:59","date_gmt":"2026-02-15T17:02:59","guid":{"rendered":"http:\/\/behavior-tools.com\/?page_id=31"},"modified":"2026-02-15T17:02:59","modified_gmt":"2026-02-15T17:02:59","slug":"novel-object-recognition-nor-fr","status":"publish","type":"page","link":"https:\/\/behavior-tools.com\/index.php\/novel-object-recognition-nor-fr\/","title":{"rendered":"NOVEL OBJECT RECOGNITION (NOR) (FR)"},"content":{"rendered":"\n

R\u00e9sum\u00e9 scientifique<\/h2>\n\n\n\n

Le Novel Object Recognition (NOR) \u00e9value la m\u00e9moire de reconnaissance bas\u00e9e sur la pr\u00e9f\u00e9rence spontan\u00e9e pour la nouveaut\u00e9. Adapt\u00e9 aux t\u00e9l\u00e9ost\u00e9ens dans les ann\u00e9es 2010, il permet d\u2019\u00e9tudier la m\u00e9moire d\u00e9clarative-like et les alt\u00e9rations neurod\u00e9g\u00e9n\u00e9ratives.<\/p>\n\n\n\n

\n\n\n\n

1. Contexte historique<\/h2>\n\n\n\n

Paradigme original chez le rat : ann\u00e9es 1980.<\/p>\n\n\n\n

Adaptation zebrafish :<\/p>\n\n\n\n

Ennaceur adaptation \u2192
May et al., 2016. Behavioural Brain Research<\/em>
DOI: 10.1016\/j.bbr.2015.11.025<\/p>\n\n\n\n

\n\n\n\n

2. Fondements neurobiologiques<\/h2>\n\n\n\n
    \n
  • Pallium dorsal (homologue hippocampe)<\/li>\n\n\n\n
  • Neurogen\u00e8se adulte<\/li>\n\n\n\n
  • Plasticit\u00e9 synaptique AMPA\/NMDA<\/li>\n<\/ul>\n\n\n\n
    \n\n\n\n

    3. Objectif<\/h2>\n\n\n\n

    Mesurer :<\/p>\n\n\n\n

      \n
    • Index discrimination (DI)<\/li>\n\n\n\n
    • Temps exploration objet nouveau<\/li>\n\n\n\n
    • M\u00e9moire court et long terme<\/li>\n<\/ul>\n\n\n\n
      \n\n\n\n

      4. M\u00e9thodologie standardis\u00e9e<\/h2>\n\n\n\n

      Phase habituation<\/h3>\n\n\n\n
        \n
      • Cuve neutre 10 min\/jour \u00d7 2 jours<\/li>\n<\/ul>\n\n\n\n

        Phase familiarisation<\/h3>\n\n\n\n
          \n
        • Deux objets identiques<\/li>\n\n\n\n
        • 10 minutes exploration<\/li>\n<\/ul>\n\n\n\n

          Phase test (1h ou 24h plus tard)<\/h3>\n\n\n\n
            \n
          • 1 objet familier + 1 nouveau<\/li>\n<\/ul>\n\n\n\n

            Param\u00e8tres<\/h3>\n\n\n\n
              \n
            • Temps exploration<\/li>\n\n\n\n
            • Latence premier contact<\/li>\n\n\n\n
            • Ratio discrimination = (N-F)\/(N+F)<\/li>\n<\/ul>\n\n\n\n
              \n\n\n\n

              5. Analyse statistique<\/h2>\n\n\n\n
                \n
              • Test t appari\u00e9<\/li>\n\n\n\n
              • ANOVA deux facteurs (traitement \u00d7 d\u00e9lai)<\/li>\n\n\n\n
              • Analyse m\u00e9moire consolidation<\/li>\n<\/ul>\n\n\n\n
                \n\n\n\n

                6. Applications<\/h2>\n\n\n\n
                  \n
                • Mod\u00e8les Alzheimer-like<\/li>\n\n\n\n
                • Stress chronique<\/li>\n\n\n\n
                • M\u00e9taux lourds (Pb, Hg)<\/li>\n\n\n\n
                • Inhibiteurs cholinest\u00e9rase<\/li>\n<\/ul>\n\n\n\n
                  \n\n\n\n

                  7. Limites<\/h2>\n\n\n\n
                    \n
                  • Biais sensoriel visuel<\/li>\n\n\n\n
                  • Effet anxi\u00e9t\u00e9<\/li>\n\n\n\n
                  • Habituation rapide<\/li>\n<\/ul>\n\n\n\n
                    \n\n\n\n

                    8. OCDE<\/h2>\n\n\n\n

                    Compl\u00e9ment potentiel aux \u00e9valuations DNT.<\/p>\n\n\n\n

                    Liens :<\/p>\n\n\n\n

                      \n
                    • OECD TG 236<\/li>\n\n\n\n
                    • OECD TG 210<\/li>\n<\/ul>\n\n\n\n

                      Non reconnu comme endpoint standard r\u00e9glementaire.<\/p>\n\n\n\n

                      \n\n\n\n

                      9. R\u00e9f\u00e9rences<\/h2>\n\n\n\n
                        \n
                      1. May et al., 2016. Object recognition in zebrafish. Behavioural Brain Research<\/em>. DOI: 10.1016\/j.bbr.2015.11.025<\/li>\n\n\n\n
                      2. Braida et al., 2014. Memory and cognition in zebrafish. Psychopharmacology<\/em>. DOI: 10.1007\/s00213-014-3561-2
                        3\u201310. [Alzheimer models, stress models, neurotoxicity]<\/li>\n<\/ol>\n\n\n\n

                        <\/p>\n","protected":false},"excerpt":{"rendered":"

                        R\u00e9sum\u00e9 scientifique Le Novel Object Recognition (NOR) \u00e9value la m\u00e9moire de reconnaissance bas\u00e9e sur la pr\u00e9f\u00e9rence spontan\u00e9e pour la nouveaut\u00e9. Adapt\u00e9 aux t\u00e9l\u00e9ost\u00e9ens dans les ann\u00e9es 2010, il permet d\u2019\u00e9tudier la m\u00e9moire d\u00e9clarative-like et les alt\u00e9rations neurod\u00e9g\u00e9n\u00e9ratives. 1. Contexte historique Paradigme original chez le rat : ann\u00e9es 1980. Adaptation zebrafish : Ennaceur adaptation \u2192May et […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-31","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/31","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/comments?post=31"}],"version-history":[{"count":1,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/31\/revisions"}],"predecessor-version":[{"id":32,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/31\/revisions\/32"}],"wp:attachment":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/media?parent=31"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}