{"id":35,"date":"2026-02-15T17:05:37","date_gmt":"2026-02-15T17:05:37","guid":{"rendered":"http:\/\/behavior-tools.com\/?page_id=35"},"modified":"2026-02-15T17:05:37","modified_gmt":"2026-02-15T17:05:37","slug":"five-choice-serial-reaction-time-task-5-csrtt-fr","status":"publish","type":"page","link":"https:\/\/behavior-tools.com\/index.php\/five-choice-serial-reaction-time-task-5-csrtt-fr\/","title":{"rendered":"FIVE CHOICE SERIAL REACTION TIME TASK (5-CSRTT) (FR)"},"content":{"rendered":"\n

R\u00e9sum\u00e9 scientifique<\/h2>\n\n\n\n

Le 5-Choice Serial Reaction Time Task (5-CSRTT) est un paradigme d\u2019attention soutenue et de contr\u00f4le inhibiteur d\u00e9riv\u00e9 des mod\u00e8les rongeurs des ann\u00e9es 1980. Son adaptation au zebrafish adulte permet d\u2019explorer les m\u00e9canismes neurocognitifs impliqu\u00e9s dans l\u2019impulsivit\u00e9, les troubles attentionnels et la modulation cholinergique.<\/p>\n\n\n\n

\n\n\n\n

1. Contexte historique<\/h2>\n\n\n\n

Paradigme original :
Robbins, 1998 \u2013 contr\u00f4le attentionnel chez le rat.<\/p>\n\n\n\n

Adaptation zebrafish :<\/p>\n\n\n\n

Parker et al., 2012. Psychopharmacology<\/em>
DOI: 10.1007\/s00213-012-2681-4<\/p>\n\n\n\n

Parker et al., 2014. Neuropsychopharmacology<\/em>
DOI: 10.1038\/npp.2013.285<\/p>\n\n\n\n

\n\n\n\n

2. Fondements neurobiologiques<\/h2>\n\n\n\n
    \n
  • Syst\u00e8me cholinergique basal<\/li>\n\n\n\n
  • Dopamine D1\/D2<\/li>\n\n\n\n
  • Pallium m\u00e9dian (homologue cortex pr\u00e9frontal fonctionnel)<\/li>\n\n\n\n
  • Contr\u00f4le top-down<\/li>\n<\/ul>\n\n\n\n
    \n\n\n\n

    3. Objectif scientifique<\/h2>\n\n\n\n

    Mesurer :<\/p>\n\n\n\n

      \n
    • Attention soutenue<\/li>\n\n\n\n
    • Impulsivit\u00e9 pr\u00e9matur\u00e9e<\/li>\n\n\n\n
    • Omissions<\/li>\n\n\n\n
    • Temps de r\u00e9action<\/li>\n<\/ul>\n\n\n\n
      \n\n\n\n

      4. M\u00e9thodologie exp\u00e9rimentale standardis\u00e9e<\/h2>\n\n\n\n

      Dispositif<\/h3>\n\n\n\n
        \n
      • Chambre op\u00e9rante aquatique compartiment\u00e9e<\/li>\n\n\n\n
      • 5 fen\u00eatres LED<\/li>\n\n\n\n
      • Distributeur alimentaire automatis\u00e9<\/li>\n<\/ul>\n\n\n\n

        Protocole<\/h3>\n\n\n\n
          \n
        1. Phase d\u2019entra\u00eenement (2\u20133 semaines)<\/li>\n\n\n\n
        2. Stimulus lumineux al\u00e9atoire (1\u20135 s)<\/li>\n\n\n\n
        3. R\u00e9ponse correcte \u2192 r\u00e9compense<\/li>\n\n\n\n
        4. R\u00e9ponse pr\u00e9matur\u00e9e \u2192 timeout<\/li>\n<\/ol>\n\n\n\n

          Param\u00e8tres principaux<\/h3>\n\n\n\n
            \n
          • % r\u00e9ponses correctes<\/li>\n\n\n\n
          • % omissions<\/li>\n\n\n\n
          • R\u00e9ponses pr\u00e9matur\u00e9es<\/li>\n\n\n\n
          • Latence r\u00e9ponse<\/li>\n<\/ul>\n\n\n\n

            Substances de validation<\/h3>\n\n\n\n
              \n
            • Atomox\u00e9tine (r\u00e9duction impulsivit\u00e9)<\/li>\n\n\n\n
            • Nicotine (modulation attention)<\/li>\n<\/ul>\n\n\n\n
              \n\n\n\n

              5. Analyse statistique<\/h2>\n\n\n\n
                \n
              • ANOVA \u00e0 mesures r\u00e9p\u00e9t\u00e9es<\/li>\n\n\n\n
              • Mod\u00e8les mixtes hi\u00e9rarchiques<\/li>\n\n\n\n
              • Analyse impulsivit\u00e9 (ratio pr\u00e9matur\u00e9)<\/li>\n\n\n\n
              • Correction Holm-Bonferroni<\/li>\n<\/ul>\n\n\n\n
                \n\n\n\n

                6. Applications<\/h2>\n\n\n\n
                  \n
                • Mod\u00e8les TDAH<\/li>\n\n\n\n
                • \u00c9tudes dopaminergiques<\/li>\n\n\n\n
                • Effets neurotoxiques subl\u00e9taux<\/li>\n\n\n\n
                • Screening cognition executive<\/li>\n<\/ul>\n\n\n\n
                  \n\n\n\n

                  7. Limites<\/h2>\n\n\n\n
                    \n
                  • Temps d\u2019entra\u00eenement long<\/li>\n\n\n\n
                  • Variabilit\u00e9 motivation alimentaire<\/li>\n\n\n\n
                  • Infrastructure co\u00fbteuse<\/li>\n<\/ul>\n\n\n\n
                    \n\n\n\n

                    8. Section OCDE<\/h2>\n\n\n\n

                    Non int\u00e9gr\u00e9 dans TG actuelles.<\/p>\n\n\n\n

                    Potentiel dans :<\/p>\n\n\n\n

                      \n
                    • OECD DNT conceptual framework<\/li>\n\n\n\n
                    • Tests m\u00e9canistiques cognitifs avanc\u00e9s<\/li>\n<\/ul>\n\n\n\n

                      Peut servir d\u2019endpoint compl\u00e9mentaire pour neurotoxicit\u00e9 fonctionnelle.<\/p>\n\n\n\n

                      \n\n\n\n

                      9. R\u00e9f\u00e9rences (r\u00e9centes \u2192 anciennes)<\/h2>\n\n\n\n
                        \n
                      1. Parker et al., 2014. Impulsivity and zebrafish 5-CSRTT. Neuropsychopharmacology<\/em>. DOI: 10.1038\/npp.2013.285<\/li>\n\n\n\n
                      2. Parker et al., 2012. Zebrafish attention model. Psychopharmacology<\/em>. DOI: 10.1007\/s00213-012-2681-4<\/li>\n\n\n\n
                      3. Bari et al., 2008. The 5-CSRTT review. Nature Protocols<\/em>. DOI: 10.1038\/nprot.2008.41
                        4\u201310. [Impulsivit\u00e9, cholinergique, toxicit\u00e9 cognitive]<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

                        R\u00e9sum\u00e9 scientifique Le 5-Choice Serial Reaction Time Task (5-CSRTT) est un paradigme d\u2019attention soutenue et de contr\u00f4le inhibiteur d\u00e9riv\u00e9 des mod\u00e8les rongeurs des ann\u00e9es 1980. Son adaptation au zebrafish adulte permet d\u2019explorer les m\u00e9canismes neurocognitifs impliqu\u00e9s dans l\u2019impulsivit\u00e9, les troubles attentionnels et la modulation cholinergique. 1. Contexte historique Paradigme original :Robbins, 1998 \u2013 contr\u00f4le attentionnel […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-35","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/35","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/comments?post=35"}],"version-history":[{"count":1,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/35\/revisions"}],"predecessor-version":[{"id":36,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/35\/revisions\/36"}],"wp:attachment":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/media?parent=35"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}