{"id":39,"date":"2026-02-15T17:07:55","date_gmt":"2026-02-15T17:07:55","guid":{"rendered":"http:\/\/behavior-tools.com\/?page_id=39"},"modified":"2026-02-15T17:07:55","modified_gmt":"2026-02-15T17:07:55","slug":"startle-response-prepulse-inhibition-ppi-fr","status":"publish","type":"page","link":"https:\/\/behavior-tools.com\/index.php\/startle-response-prepulse-inhibition-ppi-fr\/","title":{"rendered":"STARTLE RESPONSE & PREPULSE INHIBITION (PPI) (FR)"},"content":{"rendered":"\n

R\u00e9sum\u00e9 scientifique<\/h2>\n\n\n\n

Le Startle Response Test et la Prepulse Inhibition (PPI) \u00e9valuent les circuits sensorimoteurs et le filtrage sensoriel. La PPI constitue un biomarqueur translational robuste des troubles schizophr\u00e9niques et des alt\u00e9rations dopaminergiques.<\/p>\n\n\n\n

\n\n\n\n

1. Contexte historique<\/h2>\n\n\n\n

PPI d\u00e9crite chez le rongeur dans les ann\u00e9es 1960.<\/p>\n\n\n\n

Adaptation zebrafish larvaire :<\/p>\n\n\n\n

Burgess & Granato, 2007. Journal of Neuroscience<\/em>
DOI: 10.1523\/JNEUROSCI.3687-06.2007<\/p>\n\n\n\n

\n\n\n\n

2. Fondements neurobiologiques<\/h2>\n\n\n\n
    \n
  • Cellules de Mauthner<\/li>\n\n\n\n
  • Circuits r\u00e9ticulospinaux<\/li>\n\n\n\n
  • Dopamine m\u00e9senc\u00e9phale<\/li>\n\n\n\n
  • Glutamate NMDA<\/li>\n<\/ul>\n\n\n\n
    \n\n\n\n

    3. Objectif<\/h2>\n\n\n\n

    Mesurer :<\/p>\n\n\n\n

      \n
    • Amplitude startle<\/li>\n\n\n\n
    • Latence r\u00e9ponse<\/li>\n\n\n\n
    • % inhibition PPI<\/li>\n<\/ul>\n\n\n\n
      \n\n\n\n

      4. M\u00e9thodologie standardis\u00e9e<\/h2>\n\n\n\n

      Dispositif<\/h3>\n\n\n\n
        \n
      • Plaque 96 puits (larves 5\u20137 dpf)<\/li>\n\n\n\n
      • Stimulus acoustique\/vibratoire calibr\u00e9<\/li>\n\n\n\n
      • Cam\u00e9ra haute vitesse (1000 fps)<\/li>\n<\/ul>\n\n\n\n

        Param\u00e8tres<\/h3>\n\n\n\n
          \n
        • Distance parcourue post-stimulus<\/li>\n\n\n\n
        • R\u00e9duction amplitude avec pr\u00e9-stimulus<\/li>\n\n\n\n
        • Latence ms<\/li>\n<\/ul>\n\n\n\n

          Validation pharmacologique<\/h3>\n\n\n\n
            \n
          • MK-801 (r\u00e9duction PPI)<\/li>\n\n\n\n
          • Halop\u00e9ridol (restauration PPI)<\/li>\n<\/ul>\n\n\n\n
            \n\n\n\n

            5. Analyse statistique<\/h2>\n\n\n\n
              \n
            • ANOVA deux facteurs (stimulus \u00d7 traitement)<\/li>\n\n\n\n
            • Mod\u00e8les lin\u00e9aires g\u00e9n\u00e9ralis\u00e9s<\/li>\n\n\n\n
            • Analyse cin\u00e9matique<\/li>\n<\/ul>\n\n\n\n
              \n\n\n\n

              6. Applications<\/h2>\n\n\n\n
                \n
              • Mod\u00e8les schizophr\u00e9nie<\/li>\n\n\n\n
              • Neurotoxicit\u00e9 d\u00e9veloppementale<\/li>\n\n\n\n
              • Screening NMDA antagonistes<\/li>\n\n\n\n
              • Effets nanoparticules<\/li>\n<\/ul>\n\n\n\n
                \n\n\n\n

                7. Limites<\/h2>\n\n\n\n
                  \n
                • Sensibilit\u00e9 calibration sonore<\/li>\n\n\n\n
                • Variabilit\u00e9 stade d\u00e9veloppemental<\/li>\n\n\n\n
                • Fatigue sensorielle<\/li>\n<\/ul>\n\n\n\n
                  \n\n\n\n

                  8. OCDE<\/h2>\n\n\n\n

                  Fort potentiel pour int\u00e9gration dans :<\/p>\n\n\n\n

                    \n
                  • OECD DNT battery<\/li>\n\n\n\n
                  • TG 236 (compl\u00e9ment fonctionnel)<\/li>\n<\/ul>\n\n\n\n

                    Biomarqueur m\u00e9canistique prometteur.<\/p>\n\n\n\n

                    \n\n\n\n

                    9. R\u00e9f\u00e9rences<\/h2>\n\n\n\n
                      \n
                    1. Burgess & Granato, 2007. Sensorimotor gating in zebrafish. Journal of Neuroscience<\/em>. DOI: 10.1523\/JNEUROSCI.3687-06.2007<\/li>\n\n\n\n
                    2. Sledge et al., 2011. PPI in zebrafish larvae. Neurotoxicology and Teratology<\/em>. DOI: 10.1016\/j.ntt.2011.02.005
                      3\u201310. [Schizophrenia models, dopaminergic modulation]<\/li>\n<\/ol>\n\n\n\n

                      <\/p>\n","protected":false},"excerpt":{"rendered":"

                      R\u00e9sum\u00e9 scientifique Le Startle Response Test et la Prepulse Inhibition (PPI) \u00e9valuent les circuits sensorimoteurs et le filtrage sensoriel. La PPI constitue un biomarqueur translational robuste des troubles schizophr\u00e9niques et des alt\u00e9rations dopaminergiques. 1. Contexte historique PPI d\u00e9crite chez le rongeur dans les ann\u00e9es 1960. Adaptation zebrafish larvaire : Burgess & Granato, 2007. Journal of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-39","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":1,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/39\/revisions"}],"predecessor-version":[{"id":40,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/39\/revisions\/40"}],"wp:attachment":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/media?parent=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}