{"id":41,"date":"2026-02-15T17:09:03","date_gmt":"2026-02-15T17:09:03","guid":{"rendered":"http:\/\/behavior-tools.com\/?page_id=41"},"modified":"2026-02-15T17:09:03","modified_gmt":"2026-02-15T17:09:03","slug":"larval-locomotor-activity-test-fr","status":"publish","type":"page","link":"https:\/\/behavior-tools.com\/index.php\/larval-locomotor-activity-test-fr\/","title":{"rendered":"LARVAL LOCOMOTOR ACTIVITY TEST (FR)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">R\u00e9sum\u00e9 scientifique<\/h2>\n\n\n\n<p>Le Larval Locomotor Activity Test (LLAT) est un test \u00e0 haut d\u00e9bit \u00e9valuant l\u2019activit\u00e9 motrice spontan\u00e9e des larves de zebrafish. Il constitue un endpoint central en toxicologie d\u00e9veloppementale et screening pharmacologique.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">1. Contexte historique<\/h2>\n\n\n\n<p>High-throughput behavior :<\/p>\n\n\n\n<p>MacPhail et al., 2009. <em>Neurotoxicology and Teratology<\/em><br>DOI: 10.1016\/j.ntt.2008.10.005<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">2. Fondements neurobiologiques<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>D\u00e9veloppement motoneuronal<\/li>\n\n\n\n<li>Circuits glutamatergiques<\/li>\n\n\n\n<li>Maturation HPI axis<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">3. Objectif<\/h2>\n\n\n\n<p>Mesurer :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Distance totale<\/li>\n\n\n\n<li>Burst activity<\/li>\n\n\n\n<li>R\u00e9ponse lumi\u00e8re\/obscurit\u00e9<\/li>\n\n\n\n<li>Hyper\/hypoactivit\u00e9<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">4. M\u00e9thodologie standardis\u00e9e<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Dispositif<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Plaque 96 ou 384 puits<\/li>\n\n\n\n<li>5\u20137 dpf<\/li>\n\n\n\n<li>Cycle lumi\u00e8re\/obscurit\u00e9 10\/10 min<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Param\u00e8tres<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Distance cumul\u00e9e<\/li>\n\n\n\n<li>Vitesse moyenne<\/li>\n\n\n\n<li>Indice photomoteur<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Contr\u00f4les<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Caffeine (hyperactivit\u00e9)<\/li>\n\n\n\n<li>Diaz\u00e9pam (hypoactivit\u00e9)<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">5. Analyse statistique<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Courbe activit\u00e9 temporelle<\/li>\n\n\n\n<li>AUC<\/li>\n\n\n\n<li>Clustering comportemental<\/li>\n\n\n\n<li>Analyse dose-r\u00e9ponse (EC50)<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">6. Applications<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Neurotoxicit\u00e9 d\u00e9veloppementale<\/li>\n\n\n\n<li>M\u00e9taux lourds<\/li>\n\n\n\n<li>Pesticides<\/li>\n\n\n\n<li>Nanomat\u00e9riaux<\/li>\n\n\n\n<li>Screening pharmaceutique<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">7. Limites<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sensibilit\u00e9 lumi\u00e8re<\/li>\n\n\n\n<li>Effet densit\u00e9<\/li>\n\n\n\n<li>D\u00e9veloppement asynchrone<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">8. OCDE<\/h2>\n\n\n\n<p>Directement pertinent pour :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>OECD TG 236 (FET)<\/li>\n\n\n\n<li>OECD TG 212 (Early-life stage)<\/li>\n<\/ul>\n\n\n\n<p>Fortement utilis\u00e9 dans batteries DNT \u00e9mergentes.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">9. R\u00e9f\u00e9rences<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>MacPhail et al., 2009. Locomotor activity in zebrafish larvae. <em>Neurotoxicology and Teratology<\/em>. DOI: 10.1016\/j.ntt.2008.10.005<\/li>\n\n\n\n<li>Kokel et al., 2010. Rapid behavior profiling. <em>Nature Chemical Biology<\/em>. DOI: 10.1038\/nchembio.307<br>3\u201310. [High-throughput screening, toxicology studies]<\/li>\n<\/ol>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>R\u00e9sum\u00e9 scientifique Le Larval Locomotor Activity Test (LLAT) est un test \u00e0 haut d\u00e9bit \u00e9valuant l\u2019activit\u00e9 motrice spontan\u00e9e des larves de zebrafish. Il constitue un endpoint central en toxicologie d\u00e9veloppementale et screening pharmacologique. 1. Contexte historique High-throughput behavior : MacPhail et al., 2009. Neurotoxicology and TeratologyDOI: 10.1016\/j.ntt.2008.10.005 2. Fondements neurobiologiques 3. Objectif Mesurer : 4. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-41","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/41","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/comments?post=41"}],"version-history":[{"count":1,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/41\/revisions"}],"predecessor-version":[{"id":42,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/41\/revisions\/42"}],"wp:attachment":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/media?parent=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}