{"id":64,"date":"2026-02-18T20:01:19","date_gmt":"2026-02-18T20:01:19","guid":{"rendered":"http:\/\/behavior-tools.com\/?page_id=64"},"modified":"2026-02-18T20:01:19","modified_gmt":"2026-02-18T20:01:19","slug":"y-maze-en","status":"publish","type":"page","link":"https:\/\/behavior-tools.com\/index.php\/y-maze-en\/","title":{"rendered":"Y-MAZE (EN)"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">Y-Maze Test in Zebrafish<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">Scientific Overview<\/h2>\n\n\n\n<p>The Y-Maze is a spatial working memory assay derived from rodent paradigms developed in the 1950s\u20131960s. In zebrafish, it measures spontaneous alternation behavior and spatial exploration patterns.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">1. Historical Background<\/h2>\n\n\n\n<p>Adapted to zebrafish in the early 2000s.<\/p>\n\n\n\n<p>Key references:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cognato et al., 2012 \u2014 DOI: 10.1016\/j.bbr.2012.03.006<\/li>\n\n\n\n<li>Aoki et al., 2015 \u2014 DOI: 10.1038\/srep13322<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">2. Neurobiological Basis<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dorsal pallium (hippocampal homologue)<\/li>\n\n\n\n<li>Dopaminergic modulation<\/li>\n\n\n\n<li>Glutamatergic plasticity<\/li>\n\n\n\n<li>Cholinergic signaling<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">3. Objectives<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Working memory<\/li>\n\n\n\n<li>Cognitive flexibility<\/li>\n\n\n\n<li>Spatial discrimination<\/li>\n\n\n\n<li>Stress-induced cognitive deficits<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">4. Standardized Methodology<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Apparatus<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Three identical arms (25 \u00d7 8 cm)<\/li>\n\n\n\n<li>120\u00b0 angle configuration<\/li>\n\n\n\n<li>Opaque walls<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Protocol<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Single 8-minute trial<\/li>\n\n\n\n<li>Free exploration<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Parameters<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Spontaneous alternation %<\/li>\n\n\n\n<li>Number of entries<\/li>\n\n\n\n<li>Arm sequence patterns<\/li>\n\n\n\n<li>Latency<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">5. Statistical Analysis<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Alternation calculation:<br>% Alternation = (Actual alternations \/ Possible alternations) \u00d7 100<\/li>\n\n\n\n<li>ANOVA<\/li>\n\n\n\n<li>Mixed-effects modeling<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">6. Applications<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Alzheimer-like models<\/li>\n\n\n\n<li>Chronic stress models<\/li>\n\n\n\n<li>Heavy metal neurotoxicity<\/li>\n\n\n\n<li>Cognitive drug screening<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">7. Limitations<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Locomotor confounding<\/li>\n\n\n\n<li>Lighting sensitivity<\/li>\n\n\n\n<li>Stress variability<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">8. OECD Context<\/h2>\n\n\n\n<p>Potential cognitive endpoint within Developmental Neurotoxicity (DNT) frameworks.<\/p>\n\n\n\n<p>Complementary to TG 236 and TG 210.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">9. References<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cognato et al., 2012. DOI: 10.1016\/j.bbr.2012.03.006<\/li>\n\n\n\n<li>Aoki et al., 2015. DOI: 10.1038\/srep13322<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Y-Maze Test in Zebrafish Scientific Overview The Y-Maze is a spatial working memory assay derived from rodent paradigms developed in the 1950s\u20131960s. In zebrafish, it measures spontaneous alternation behavior and spatial exploration patterns. 1. Historical Background Adapted to zebrafish in the early 2000s. Key references: 2. Neurobiological Basis 3. Objectives 4. Standardized Methodology Apparatus Protocol [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-64","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/64","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/comments?post=64"}],"version-history":[{"count":1,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/64\/revisions"}],"predecessor-version":[{"id":65,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/64\/revisions\/65"}],"wp:attachment":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/media?parent=64"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}