{"id":76,"date":"2026-02-18T20:14:30","date_gmt":"2026-02-18T20:14:30","guid":{"rendered":"http:\/\/behavior-tools.com\/?page_id=76"},"modified":"2026-02-18T20:14:30","modified_gmt":"2026-02-18T20:14:30","slug":"conditioned-place-preference-cpp-en-2","status":"publish","type":"page","link":"https:\/\/behavior-tools.com\/index.php\/conditioned-place-preference-cpp-en-2\/","title":{"rendered":"CONDITIONED PLACE PREFERENCE (CPP) (EN)"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">Conditioned Place Preference in Zebrafish<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">Scientific Overview<\/h2>\n\n\n\n<p>Conditioned Place Preference (CPP) evaluates reward learning and drug reinforcement in zebrafish (Danio rerio). It is widely used in addiction research and translational psychopharmacology.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">1. Historical Background<\/h2>\n\n\n\n<p>Adapted from rodent models in the late 2000s.<\/p>\n\n\n\n<p>Key studies:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Darland &amp; Dowling, 2001. <em>Behavioral Neuroscience<\/em><br>DOI: 10.1037\/0735-7044.115.6.1247<\/li>\n\n\n\n<li>Mathur et al., 2011. <em>Neuropsychopharmacology<\/em><br>DOI: 10.1038\/npp.2011.71<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">2. Neurobiological Basis<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mesolimbic dopaminergic pathway<\/li>\n\n\n\n<li>NMDA receptor signaling<\/li>\n\n\n\n<li>Opioid receptor systems<\/li>\n\n\n\n<li>Serotonergic modulation<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">3. Scientific Objectives<\/h2>\n\n\n\n<p>Assess:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reward learning<\/li>\n\n\n\n<li>Drug reinforcement<\/li>\n\n\n\n<li>Aversion conditioning<\/li>\n\n\n\n<li>Relapse models<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">4. Standardized Experimental Methodology<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Apparatus<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Two visually distinct compartments<\/li>\n\n\n\n<li>Neutral central zone<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Phases<\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Pre-test (baseline preference)<\/li>\n\n\n\n<li>Conditioning phase (drug-paired exposure)<\/li>\n\n\n\n<li>Post-test (preference assessment)<\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Compounds Tested<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ethanol<\/li>\n\n\n\n<li>Cocaine<\/li>\n\n\n\n<li>Nicotine<\/li>\n\n\n\n<li>Morphine<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Endpoints<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Time spent in drug-paired compartment<\/li>\n\n\n\n<li>Preference index<\/li>\n\n\n\n<li>Locomotor activity<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">5. Statistical Analysis<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Paired t-test (pre vs post)<\/li>\n\n\n\n<li>Mixed ANOVA<\/li>\n\n\n\n<li>Effect size calculation<\/li>\n\n\n\n<li>Extinction curve modeling<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">6. Applications<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Addiction research<\/li>\n\n\n\n<li>Neurodevelopmental exposure studies<\/li>\n\n\n\n<li>Antidepressant screening<\/li>\n\n\n\n<li>Dopaminergic drug validation<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">7. Limitations<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Baseline side bias<\/li>\n\n\n\n<li>Locomotor confounding<\/li>\n\n\n\n<li>Stress influence<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">8. OECD Context<\/h2>\n\n\n\n<p>CPP is not included in current OECD TG frameworks, but may contribute to mechanistic neurotoxicity evaluation and DNT initiatives.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">9. Key Scientific References<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Darland &amp; Dowling, 2001. DOI: 10.1037\/0735-7044.115.6.1247<\/li>\n\n\n\n<li>Mathur et al., 2011. DOI: 10.1038\/npp.2011.71<\/li>\n\n\n\n<li>Kily et al., 2008. DOI: 10.1111\/j.1460-9568.2008.06095.x<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Conditioned Place Preference in Zebrafish Scientific Overview Conditioned Place Preference (CPP) evaluates reward learning and drug reinforcement in zebrafish (Danio rerio). It is widely used in addiction research and translational psychopharmacology. 1. Historical Background Adapted from rodent models in the late 2000s. Key studies: 2. Neurobiological Basis 3. Scientific Objectives Assess: 4. Standardized Experimental Methodology [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-76","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/76","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/comments?post=76"}],"version-history":[{"count":1,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/76\/revisions"}],"predecessor-version":[{"id":77,"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/pages\/76\/revisions\/77"}],"wp:attachment":[{"href":"https:\/\/behavior-tools.com\/index.php\/wp-json\/wp\/v2\/media?parent=76"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}